Science
Biology is connected. So is our thinking.
Decades of clinical knowledge. Made simple. A daily foundation built around the body, not the latest trend.
The seven biological windows
A whole-body perspective.
Every ingredient in CORE49 earns its place in one of seven connected functions. This is a lens for understanding the formula — not a promise of an individual health outcome.
Brain & mood
Focus, mood and a calm, clear mind.
Strength & longevity
Muscles, bones and the long game of ageing well.
Gut health
A well-fed gut flora and comfortable digestion.
Energy production
How your cells turn food into usable power.
Cellular health
The daily maintenance that keeps cells working well.
Cellular protection
Your defences against everyday oxidative stress.
Hydration & balance
Fluids, minerals and steady hydration.
Our own research
Real people. Real results.
We tested CORE49 at The Maas Clinic over 21 days, measuring blood markers before and after and asking participants how they felt. The results made us proud.
92%
felt more energy through the day
88%
reported a calmer, clearer mind
85%
said their daily routine felt simpler
9 in 10
want to keep their CORE49 ritual
21-day pilot at The Maas Clinic. Self-reported by participants.
“I stopped thinking about supplements. Two scoops in the morning, and I just felt more like myself.”
— Pilot participant, 21 days
Study duration
21 days, once daily
Markers measured
Homocysteine · hs-CRP · oxidation-reduction potential (ORP)
What we saw
Positive shifts across the markers we measured
The research library
The studies behind the ingredients.
Peer-reviewed research on individual ingredients, summarised in plain language. These studies inform our formulation — they evaluate single ingredients, not the finished CORE49 formula.
Creatine Monohydrate
Strength & longevity
International Society of Sports Nutrition position stand: creatine supplementation and exercise
Journal of the International Society of Sports Nutrition · 2017
One of the most studied nutrients in sports science. The review confirms creatine monohydrate supports muscle energy and training adaptation, with a strong safety record.
Read article : International Society of Sports Nutrition position stand: creatine supplementation and exerciseVitamin D3
Cellular protection
Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis
The BMJ · 2017
Pooling data from 25 trials, researchers found vitamin D supplementation supported immune defences — most clearly in people who started with low levels.
Read article : Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysisMagnesium
Hydration & balance
The effect of magnesium supplementation on primary insomnia in elderly
Journal of Research in Medical Sciences · 2012
A double-blind trial found magnesium supplementation improved sleep time and sleep quality in older adults with insomnia.
Read article : The effect of magnesium supplementation on primary insomnia in elderlyCoenzyme Q10
Energy production
The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure (Q-SYMBIO)
JACC: Heart Failure · 2014
In this controlled trial, long-term CoQ10 alongside standard care supported heart function in people with chronic heart failure — a window into cellular energy.
Read article : The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure (Q-SYMBIO)Red Beetroot (dietary nitrate)
Strength & longevity
Effects of dietary nitrate on oxygen cost during exercise
Acta Physiologica · 2007
Beetroot nitrate reduced the oxygen cost of exercise — the same effort for less energy — opening a field of research on blood flow and stamina.
Read article : Effects of dietary nitrate on oxygen cost during exerciseCreatine Monohydrate
Brain & mood
Creatine supplementation and brain health
Nutrients · 2021
Beyond muscles: emerging research explores how creatine supports energy supply in the brain, particularly during stress, poor sleep and ageing.
Read article : Creatine supplementation and brain healthL-Theanine
Brain & mood
Effects of L-theanine administration on stress-related symptoms and cognitive functions in healthy adults
Nutrients · 2019
Four weeks of L-theanine, the calm-focus compound in green tea, supported stress-related symptoms and verbal fluency in healthy adults.
Read article : Effects of L-theanine administration on stress-related symptoms and cognitive functions in healthy adultsTurmeric (curcumin)
Cellular protection
Curcumin: a review of its effects on human health
Foods · 2017
A broad review of the golden spice: antioxidant activity, joint comfort and the absorption challenge that shaped how curcumin is formulated.
Read article : Curcumin: a review of its effects on human healthZinc
Cellular protection
Zinc lozenges and the common cold: a meta-analysis
JRSM Open · 2017
Across controlled trials, zinc shortened the duration of common colds — one of the clearest examples of a mineral supporting immune function.
Read article : Zinc lozenges and the common cold: a meta-analysisB vitamins (B6, B9, B12)
Cellular health
Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment
PLOS ONE · 2010
The VITACOG trial found that B6, folate and B12 — the methylation trio — slowed brain shrinkage in older adults with raised homocysteine.
Read article : Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairmentChicory Inulin (prebiotic fibre)
Gut health
ISAPP consensus statement on the definition and scope of prebiotics
Nature Reviews Gastroenterology & Hepatology · 2017
The expert consensus on prebiotics: fibres like inulin selectively feed beneficial gut bacteria, with effects reaching well beyond digestion.
Read article : ISAPP consensus statement on the definition and scope of prebioticsVitamin K2 (MK-7)
Strength & longevity
Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women
Osteoporosis International · 2013
Three years of daily K2 (MK-7) supported bone strength — evidence for the vitamin that helps guide calcium to where it belongs.
Read article : Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women