Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis
Pooling data from 25 trials, researchers found vitamin D supplementation supported immune defences — most clearly in people who started with low levels.
An independent summary of published ingredient research, not the original paper or a clinical study of CORE49.
What the research found
Researchers combined individual participant data from 25 randomised trials. They found a lower overall risk of acute respiratory tract infection, with the greatest benefit among people with very low vitamin D levels and those receiving regular rather than large intermittent doses.
The important context
Baseline vitamin D status and dosing pattern mattered. This is a 2017 analysis, not a guarantee of protection or a substitute for current clinical guidance.
Where CORE49 fits
This paper informs our understanding of an individual ingredient. It did not evaluate the finished CORE49 formula. Study populations, ingredient forms and amounts can differ from those in our daily drink; ingredient evidence and formula evidence are not interchangeable.
